تفاعل #555278

معادلة التفاعل

Ethyl 2-phenyl-benzothiazole-6-carboxylate

LiOH

HCl

→

1z

المردود 100.4%

2-Phenyl-benzothiazole-6-carboxylic acid

المردود 100.4%

المذيبات

THF

H2O

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe resulting mixture was extracted with EtOAc (2×)
2. 2
   غسيلThe organic solution was washed with aq. NaCl
3. 3
   تجفيفdried over Na2SO4
4. 4
   تركيزconcentrated

الإجراء التجريبي

Ethyl 2-phenyl-benzothiazole-6-carboxylate 1y (220 mg, 0.78 mmol) was stirred with LiOH (74 mg, 3.1 mmol) in THF (4 mL) and H2O (4 mL) for 16 h. Aqueous 1N HCl solution was added to the mixture to adjust pH to 3˜4. The resulting mixture was extracted with EtOAc (2×). The organic solution was washed with aq. NaCl, dried over Na2SO4 and concentrated to give 1z (200 mg).

المصدر