تفاعل #554701

معادلة التفاعل

benzyl piperazine-1-carboxylate

1,2-epoxycyclopentane

→

expected compound

المردود 44.2%

Benzyl 4-(trans-2-hydroxycyclopentyl)piperazine-1-carboxylate

المردود 44.2%

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture is concentrated under vacuum
2. 2
   أخرىthe residue is purified by silica gel chromatography
3. 3
   غسيلeluting with EtOAc/MeOH mixture

الإجراء التجريبي

A solution of 0.524 g of benzyl piperazine-1-carboxylate is cooled to 0° C., 0.2 g of 1,2-epoxycyclopentane is added and it is heated at 80° C. for four days. The reaction mixture is concentrated under vacuum and the residue is purified by silica gel chromatography, eluting with EtOAc/MeOH mixture. 0.32 g of the expected compound is obtained.

المصدر