تفاعل #55461

معادلة التفاعل

2-(1-Benzyl-5-methyl-4-imidazolyl)-4-oxotetrahydrothiophene

ethanol

hydroxyamine hydrochloride

sodium acetate

→

2-(1-Benzyl-5-methyl-4-imidazolyl)-4-oxotetrahydrothiophene oxime

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture is concentrated in vacuo
2. 2
   أخرىThe residue is triturated with chloroform
3. 3
   ترشيحthe mixture is filtered
4. 4
   استخلاصThe chloroform extract
5. 5
   تجفيفis dried over anhydrous sodium sulfate
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated in vacuo

الإجراء التجريبي

2-(1-Benzyl-5-methyl-4-imidazolyl)-4-oxotetrahydrothiophene (0.14 g., 0.5 mole) is dissolved in 1 ml. of ethanol and 1 ml. of water is added. Then hydroxyamine hydrochloride (38 mg., 0.55 mole) and sodium acetate (45 mg., 0.55 mole) are added. The mixture is stirred at room temperature overnight. The reaction mixture is concentrated in vacuo. The residue is triturated with chloroform and the mixture is filtered. The chloroform extract is dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude oxime, 2-(1-benzyl-5-methyl-4-imidazolyl)-4-oxotetrahydrothiophene oxime, is a brown viscous oil (0.15 g.).

المصدر