تفاعل #554605

معادلة التفاعل

lithium hydroxide trihydrate

ethanol

ethyl acetate

Ethyl 4,6-dibromo-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate

→

3-(2-Carboxyethyl)-4,6-dibromo-1H-indole-2-carboxylic acid

المردود 95.0%

المذيبات

hexane

THF

water

methanol

—

petrol ether

water

tetrahydrofurane

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGto stir at rt for 24 h
2. 2
   أخرىwas removed under reduced pressure
3. 3
   استخلاصthe product was extracted with diethyl ether (3×30 ml)
4. 4
   تجفيفThe organic layers were dried over magnesium sulfate
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated to dryness
7. 7
   أخرىto yield a light-beige-colored solid in 95-100% yield

الإجراء التجريبي

Ethyl 4,6-dibromo-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate (4.47 g, 10 mmol) was dissolved in 25 ml tetrahydrofurane (THF) with stirring at rt. Then a solution of 1.26 g of lithium hydroxide trihydrate (3 equiv.) in 25 ml water was added and the resulting mixture was let to stir at rt for 24 h. After completion of the reaction THF was removed under reduced pressure and the pH was adjusted to 4-5, and the product was extracted with diethyl ether (3×30 ml). The organic layers were dried over magnesium sulfate, filtered, and evaporated to dryness to yield a light-beige-colored solid in 95-100% yield. mp. 259° C.; well soluble in methanol, ethanol and ethyl acetate; slightly soluble in petrol ether, water, hexane. 1H-NMR (MeOH-d4): δ 2.67 (t, 2H, 3J=8.4 Hz, CH2); 3.71 (t, 2H, 3J=8.4 Hz, CH2); 7.42 (d, 1H, 4J=1.6 Hz, C7-H); 7.62 (d, 1H, 4J=1.6 Hz, C5-H). 13C-NMR (MeOH-d4): δ 21.4 (C-2′); 37.9 (C-1′); 115.9 (C-7); 117.0 (C-4); 118.8 (C-6); 123.9 (C-3); 125.5 (C-2); 127.9 (C-3a); 128.2 (C-5); 139.6 (C-7a); 164.6 (2′-CO2H); 170.1 (2-CO2H). LC-MS (m/z): 392.0 [M]+; 390.0 [M]−. Purity (LC-MS): 99%.

المصدر