تفاعل #55460

معادلة التفاعل

Ethyl 2-(1-benzyl-5-methyl-4-imidazolyl)-4-oxotetrahydrothiophene

water

→

2-(1-benzyl-5-methyl-4-imidazolyl)-4-oxotetrahydrothiophene

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe reaction mixture is diluted with 50 ml
2. 2
   غسيلof water and is washed with ether
3. 3
   استخلاصthe oil which separates is extracted into chloroform
4. 4
   غسيلThe extract is washed with water
5. 5
   تجفيفdried over anhydrous sodium sulfate
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated in vacuo

الإجراء التجريبي

Ethyl 2-(1-benzyl-5-methyl-4-imidazolyl)-4-oxotetrahydrothiophene-5(and/or 3)-carboxylate (12.6 g., 0.037 mole) is dissolved in 20 ml. of water containing concentrated sulfuric acid (1.11 ml., 0.02 mole) and the solution is refluxed for 31/4 hours. The reaction mixture is diluted with 50 ml. of water and is washed with ether. The aqueous layer is made basic with sodium carbonate and the oil which separates is extracted into chloroform. The extract is washed with water, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The product 2-(1-benzyl-5-methyl-4-imidazolyl)-4-oxotetrahydrothiophene is isolated a brown gum (7.8 g.).

المصدر