تفاعل #554568

معادلة التفاعل

H2O

Benzo[b]thiophene-2-ylboronic acid

9-chlorophenanthridin

sodium carbonate

→

9-Benzothienylphenanthridine

المردود 78.0%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةby refluxing under a N2 atmosphere for 5 hours
2. 2
   استخلاصthe mixture was extracted with chloroform
3. 3
   تجفيفby drying with sodium sulfate
4. 4
   ترشيحAfter filtration
5. 5
   أخرىthe filtrate was evaporated to dryness under reduced pressure
6. 6
   أخرىThe obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%)

الإجراء التجريبي

Benzo[b]thiophene-2-ylboronic acid (884 mg, 5.0 mmol) and 9-chlorophenanthridin (1.0 g, 4.8 mmol) were dissolved in tetrahydrofuran (30 ml), and palladium catalyst (160 mg, 0.14 mmol) and 2M sodium carbonate solution (20 ml) were added, followed by refluxing under a N2 atmosphere for 5 hours. The reaction solution was added to H2O and the mixture was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%).

المصدر