تفاعل #5540

معادلة التفاعل

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

phthalic anhydride

→

desired product

المردود 84.8%

5-[2-[2-(carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine

المردود 84.8%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated
2. 2
   درجة الحرارةat reflux for 5 hours
3. 3
   درجة الحرارةThe reaction mixture was cooled
4. 4
   أخرىThe crystals precipitated
5. 5
   ترشيحwere filtered off
6. 6
   غسيلwashed with chloroform
7. 7
   أخرىdried

الإجراء التجريبي

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.12 g, 5.8 mmoles) in chloroform (58 ml) was added phthalic anhydride (1.12 g, 7.56 mmoles) and the mixture was stirred at room temperature for 14 hours and then heated at reflux for 5 hours. The reaction mixture was cooled by standing. The crystals precipitated were filtered off, washed with chloroform and dried to obtain 1.68 g of the desired product (84.8%, colorless crystals).

المصدر