تفاعل #55393

معادلة التفاعل

4-hydroxymethyl-3-methylisothiazole

cysteamine hydrochloride

hydrobromic acid

→

3-methyl-4-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide

ظروف التفاعل

الإجراء التجريبي

Reacting 4-hydroxymethyl-3-methylisothiazole (3.0 g) with cysteamine hydrochloride (2.8 g) in 48% aqueous hydrobromic acid (50 ml) by the procedure of Example 42(ii) gives 3-methyl-4-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide. The base is obtained by basifying with aqueous potassium carbonate, extracting with chloroform, drying the extracts over magnesium sulphate and concentrating. Using the amine (5.0 g) as the starting material in the procedure of Example 72(ii) yields the title compound.

المصدر