تفاعل #5536

معادلة التفاعل

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

triethylamine

ethanesulfonyl chloride

→

desired product

المردود 78.2%

5-[2-(ethylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

المردود 78.2%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 1 hour
2. 2
   غسيلThe reaction mixture was washed in turn with an aqueous saturated sodium bicarbonate solution and water
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   أخرىThe residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:5)

الإجراء التجريبي

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.93 g, 10 mmoles) and triethylamine (1.53 ml, 11 mmoles) in methylene chloride (100 ml) was added ethanesulfonyl chloride (0.95 ml, 10 mmoles) at room temperature with stirring and the mixture was stirred at room temperature for 1 hour. The reaction mixture was washed in turn with an aqueous saturated sodium bicarbonate solution and water and dried over anhydrous magnesium sulfate, and then the solvent was distilled off. The residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:5) to obtain 2.23 g of the desired product (78.2%, colorless crystals).

المصدر