تفاعل #5535

معادلة التفاعل

5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

hydrogen chloride methanol

→

desired product

المردود 89.3%

5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride

المردود 89.3%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONAfter the solvent was distilled off
2. 2
   أخرىthe residue was crystallized from chloroform ether
3. 3
   أخرىThen, the crystals thus obtained
4. 4
   غسيلwere washed with ether
5. 5
   أخرىdried

الإجراء التجريبي

A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).

المصدر