تفاعل #55319

معادلة التفاعل

4-hydroxypyridine

dimethyl sulfoxide

Propargyl chloride

→

4-(propynyloxy)pyridine

المردود 3.6%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture heated at 50° for 6 hrs
2. 2
   استخلاصextracted two times with ether
3. 3
   استخلاصThe combined ether extract
4. 4
   أخرىwas dried
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated as before

الإجراء التجريبي

To a solution of 20.0 g (0.21 mole) 4-hydroxypyridine and 200 ml dimethyl sulfoxide was added 102 g (0.1 mole) silver carbonate. Propargyl chloride (22.5 g, 0.3 mole) was added to this suspension and the mixture heated at 50° for 6 hrs. After cooling to room temperature, the reaction mixture was diluted with water and extracted two times with ether. The combined ether extract was dried, filtered and concentrated as before to give 1.0 g of 4-(propynyloxy)pyridine. The product was 95% pure by vpc. The nmr and ir were compatible with the structure.

المصدر