تفاعل #5530

معادلة التفاعل

5-[3-(tert-butoxycarbonylamino)propylamino]imidazo[1,2-a]pyridine

hydrogen chloride methanol

→

desired product

المردود 83.0%

5-[3-(amino)propylamino]imidazo[1,2-a]pyridine dihydrochloride

المردود 83.0%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONAfter the solvent was distilled off
2. 2
   workup.ADDITIONethanol (15 ml) and ether (30 ml) were added to the residue
3. 3
   أخرىThen, the crystals precipitated
4. 4
   ترشيحwere filtered off
5. 5
   غسيلwashed in turn with ether

الإجراء التجريبي

To a suspension of 5-[3-(tert-butoxycarbonylamino)propylamino]imidazo[1,2-a]pyridine (1.742 g, 6 mmoles) in methylene chloride (40 ml) was added hydrogen chloride-methanol (6 ml) and the mixture was stirred at room temperature for 20 hours. After the solvent was distilled off, ethanol (15 ml) and ether (30 ml) were added to the residue. Then, the crystals precipitated were filtered off and washed in turn with ether and a small amount of ethanol to obtain 1.311 g of the desired product (83.0%, pale yellow crystals).

المصدر