تفاعل #55267

معادلة التفاعل

3(R),7-dimethyl octanoic acid ethyl ester

methanol

CHCl3

→

3(R),7-dimethyl octanoic acid

المردود 60.0%

المذيبات

NaOH

ظروف التفاعل

المعالجة

1. 1
   أخرىHydrolysis
2. 2
   أخرىto give 207 mg

الإجراء التجريبي

Hydrolysis: 400 mg. (2 mmol) of 3(R),7-dimethyl octanoic acid ethyl ester was refluxed in 6N NaOH (1 ml.) and methanol (4 ml.) for 2 hours. It was worked up as in Example 10 to give 207 mg. (60% yield) of 3(R),7-dimethyl octanoic acid (R-(+)-dihydrocitronellic acid), [α]D25 +6.81° (c=5.039, CHCl3).

المصدر