تفاعل #55240

معادلة التفاعل

N-(3-chloropropyl)morpholine

Salicylaldehyde

sodium hydride

toluene

→

product

2-[3-(4-Morpholinyl)propoxy]benzaldehyde

المذيبات

dimethylformamide

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture is heated at 105°-110° C. for 4 hours
2. 2
   درجة الحرارةcooled
3. 3
   استخلاصThe product is extracted three times with ether
4. 4
   أخرىdried
5. 5
   تركيزconcentrated on a rotary evaporator
6. 6
   workup.DISTILLATIONthe residue distilled

الإجراء التجريبي

Salicylaldehyde (17 g) is treated first with 6.7 g of 50% sodium hydride in 110 ml of dimethylformamide and then with 92 ml of a 2 N toluene solution of N-(3-chloropropyl)morpholine. The mixture is heated at 105°-110° C. for 4 hours, cooled and poured into 300 ml of water. The product is extracted three times with ether. The extracts are combined, dried, concentrated on a rotary evaporator and the residue distilled to give 32.3 g of product as an oil, boiling point 155°-160° C. at 0.1-0.2 mm of Hg.

المصدر