تفاعل #5523

معادلة التفاعل

(±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

triethylamine

2,2,2-trichloroethyl chloroformate

→

1-carbamylindoline

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe CH2Cl2 solution was extracted with water and 1N HCl
2. 2
   غسيلThe organic solution was washed with saturated NaHCO3 solution and with brine solution
3. 3
   تجفيفThe CH2Cl2 solution was dried (MgSO4)
4. 4
   تركيزconcentrated in vacuo

الإجراء التجريبي

To a solution of (±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (2.3 g, 7.7 mmol) and triethylamine (1.1 ml, 8 mmol) in 90 ml CH2Cl2 under N2 was added dropwise a solution of 2,2,2-trichloroethyl chloroformate. The reaction mixture was stirred at RT for 1 hr. The CH2Cl2 solution was extracted with water and 1N HCl. The organic solution was washed with saturated NaHCO3 solution and with brine solution. The CH2Cl2 solution was dried (MgSO4) and concentrated in vacuo to give 3.3 g of the 1-carbamylindoline.

المصدر