تفاعل #551223

معادلة التفاعل

6,7-dimethoxy-4-chloro-quinazoline

4-n-butyl-semicarbazide

→

hydrochloride

1-n-Butyl-4-(6,7-dimethoxyquinazol-4-yl)-semicarbazide hydrochloride

4-n-butyl-4-(6,7-dimethoxyquinazol-4-yl)-semi-carbazide

المذيبات

n-amyl alcohol

ظروف التفاعل

المعالجة

1. 1
   أخرىThen, the precipitate which had formed
2. 2
   ترشيحwas suction-filtered off
3. 3
   workup.ADDITIONbrought to pH 5 by the addition of 2N hydrochloric acid
4. 4
   ترشيحThe clear solution was filtered through charcoal
5. 5
   درجة الحرارةcooled
6. 6
   ترشيحsuction-filtered
7. 7
   أخرىdried in a circulating air drier

الإجراء التجريبي

3 g of 6,7-dimethoxy-4-chloro-quinazoline were stirred with 3.5 g of 4-n-butyl-semicarbazide in 100 ml of n-amyl alcohol for 2 hours at 100° C. Then, the precipitate which had formed was suction-filtered off, suspended while in hot ethanol and brought to pH 5 by the addition of 2N hydrochloric acid. The clear solution was filtered through charcoal, cooled, suction-filtered and dried in a circulating air drier. The hydrochloride of 4-n-butyl-4-(6,7-dimethoxyquinazol-4-yl)-semi-carbazide, which was obtained with a 70% yield, melted at 216°-217° C. The following compounds were obtained analogously.

المصدر