تفاعل #55103

معادلة التفاعل

4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole

methyl isocyanate

→

N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]urea

المردود 58.8%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated for 18 hours in a pressure vessel at 100°
2. 2
   درجة الحرارةAfter cooling
3. 3
   أخرىthe solid obtained
4. 4
   أخرىwas collected
5. 5
   أخرىrecrystallised from isopropyl alcohol-acetonitrile

الإجراء التجريبي

A mixture of 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole (5.1 g.) and methyl isocyanate (2.0 g.) in acetonitrile was heated for 18 hours in a pressure vessel at 100°. After cooling, the solid obtained was collected and recrystallised from isopropyl alcohol-acetonitrile to give N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]urea (4.0 g.) m.p. 158°-159°. (Found: C, 47.4; H, 7.1; N, 24.5; S, 14.1. C9H16N4OS requires: C, 47.3; H, 7.1; N, 24.5; S, 14.0).

المصدر