تفاعل #55096

معادلة التفاعل

4-hydroxymethyl-5-methylimidazole hydrochloride

cysteamine hydrochloride

→

4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride

المردود 164.7%

المذيبات

isopropyl alcohol

hydrochloric acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux for 17 hours
2. 2
   تركيزConcentration
3. 3
   أخرىfollowed by re-evaporation with water
4. 4
   أخرىafforded a residue which
5. 5
   تركيزconcentrated to low bulk
6. 6
   درجة الحرارةcooled

الإجراء التجريبي

A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in concentrated aqueous hydrochloric acid (450 ml.) was heated under reflux for 17 hours. Concentration followed by re-evaporation with water afforded a residue which was dissolved in isopropyl alcohol, concentrated to low bulk and cooled to afford 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (40.6 g.), m.p. 185°-191°.

المصدر