تفاعل #550895

معادلة التفاعل

3,4-dihydro-6,7-dimethoxy-1-[(3,4-dimethoxyphenyl)methyl]-4-isoquinoline carboxylic acid methyl ester, hydrochloride

decalin

hydrochloric acid

→

6,7-dimethoxy-1-[(3,4-dimethoxyphenyl)methyl]-4-isoquinolinecarboxylic acid methyl ester

المردود 115.3%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 2 hours
2. 2
   أخرىthe catalyst was removed by filtration
3. 3
   غسيلThe aqueous solution was washed with ether
4. 4
   استخلاصthe product was extracted with ethyl acetate
5. 5
   أخرىdried
6. 6
   أخرىevaporated

الإجراء التجريبي

A mixture of 3.9 g of 3,4-dihydro-6,7-dimethoxy-1-[(3,4-dimethoxyphenyl)methyl]-4-isoquinoline carboxylic acid methyl ester, hydrochloride, 100 ml of decalin and 2 g of 10% palladium on carbon was stirred and refluxed for 2 hours. The cooled mixture was diluted with water, acidified with 6N hydrochloric acid, and the catalyst was removed by filtration. The aqueous solution was washed with ether, made basic with excess ammonium hydroxide, and the product was extracted with ethyl acetate, dried, and evaporated to give 4.1 g of crude 6,7-dimethoxy-1-[(3,4-dimethoxyphenyl)methyl]-4-isoquinolinecarboxylic acid methyl ester. Crystallization from ether provided the analytically pure material, mp 127°-128°.

المصدر