تفاعل #55081

معادلة التفاعل

4-chlorobenzylmercaptan

ethyl α-bromopropionate

potassium carbonate

potassium iodide

→

Ethyl 2-(p-chlorobenzylthio)-propionate

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux for 6 hrs
2. 2
   ترشيحIt is filtered
3. 3
   غسيلthe precipitate is washed with acetone
4. 4
   أخرىthe filtrate is evaporated in vacuo
5. 5
   workup.ADDITION200 ml of ether are added to the residue
6. 6
   غسيلthe mixture is washed with dilute NaOH, dilute HCl and water
7. 7
   أخرىdried
8. 8
   أخرىevaporated in vacuo

الإجراء التجريبي

A mixture of 19.5 ml (0.15 mol) of 4-chlorobenzylmercaptan, 27.1 g (0.15 mol) of ethyl α-bromopropionate, 21 g of potassium carbonate and 0.1 g of potassium iodide in 100 ml of anhydrous acetone is kept under reflux for 6 hrs. It is filtered, the precipitate is washed with acetone and the filtrate is evaporated in vacuo. 200 ml of ether are added to the residue and the mixture is washed with dilute NaOH, dilute HCl and water, dried and evaporated in vacuo.

المصدر