تفاعل #5506

ord-856e1c74c5fa4bfaa718c434d3d2dcd8

معادلة التفاعل

CCOC(=O)CC(CCCCCCCCCCC(CC(=O)OCC)C(=O)O)NC(=O)OC(C)(C)C
Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate
ClCCl
methylene chloride
→
CCOC(=O)CC(N)CCCCCCCCCCC(CC(=O)OCC)C(=O)O.Cl
diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride

المتفاعلات

CCOC(=O)CC(CCCCCCCCCCC(CC(=O)OCC)C(=O)O)NC(=O)OC(C)(C)C
Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate
ClCCl
methylene chloride

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىhydrogen chloride gas is bubbled through the solution for 15 minutes
  2. 2
    أخرىThe sealed reaction
  3. 3
    أخرىthe solvent is evaporated

الإجراء التجريبي

Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate (3.98 g, 8.40 mmol) is dissolved in methylene chloride (150.0 mL), and hydrogen chloride gas is bubbled through the solution for 15 minutes. The sealed reaction is stirred for 2.5 hours, and then the solvent is evaporated to give diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US05244889uspto-grants-1993_09