تفاعل #55030

معادلة التفاعل

hydrogen

thiophene

ethanol

N-(4-piperidinyl)-2-pyrimidinamine

→

N-[1-(1-methylethyl)-4-piperidinyl]-2-pyrimidinamine

المذيبات

methanol

2-propanone

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe catalyst is filtered off
2. 2
   أخرىthe filtrate is evaporated
3. 3
   workup.DISSOLUTIONThe residue is dissolved in trichloromethane
4. 4
   غسيلThe solution is washed successively with a diluted sodium hydroxide solution and with water
5. 5
   أخرىdried
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated

الإجراء التجريبي

To 0.5 parts of a solution of 2 parts of thiophene in 40 parts of ethanol, are added 4 parts of 2-propanone, 4.5 parts of N-(4-piperidinyl)-2-pyrimidinamine and 120 parts of methanol. The whole is hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is dissolved in trichloromethane. The solution is washed successively with a diluted sodium hydroxide solution and with water, dried, filtered and evaporated, yielding 3 parts of N-[1-(1-methylethyl)-4-piperidinyl]-2-pyrimidinamine as a residue.

المصدر