تفاعل #5502

معادلة التفاعل

Ethyl 3-t-butoxycarbonylmethylidene-2-oxo-1-azacyclodecane-10-carboxylate

→

ethyl 3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane-10-carboxylate

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction is filtered through Celite
2. 2
   أخرىthe solvent is removed
3. 3
   أخرىThe crude product is purified by silica gel chromatography (20% ethyl acetate/hexane)

الإجراء التجريبي

Ethyl 3-t-butoxycarbonylmethylidene-2-oxo-1-azacyclodecane-10-carboxylate (2.85 g, 8.4 mmol) is dissolved in ethyl acetate (75 mL). 10% Pd/C (2.0 g) is added, and the reaction is stirred under an atmosphere of hydrogen for 4.5 hours. The reaction is filtered through Celite, and the solvent is removed. The crude product is purified by silica gel chromatography (20% ethyl acetate/hexane) to give separately the two diastereomers of ethyl 3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane-10-carboxylate.

المصدر