تفاعل #54926

معادلة التفاعل

benzimidic acid 2-methylhydrazide hydrochloride

o-toluic acid chloride

→

1-Methyl-5-(o-tolyl)-3-phenyl-1,2,4-triazole

المردود 76.0%

المذيبات

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONA mixture of 0.56 g
2. 2
   درجة الحرارةAfter cooling
3. 3
   أخرىthe hydrochloride of the triazole is collected
4. 4
   ترشيحon filter
5. 5
   استخلاصThe free base is extracted with diethyl ether
6. 6
   تجفيفthe organic phase, after drying over sodium sulfate
7. 7
   أخرىis evaporated
8. 8
   workup.DISTILLATIONThe crude compound is purified by distillation at 160° C./0.1 mm Hg

الإجراء التجريبي

A mixture of 0.56 g. of benzimidic acid 2-methylhydrazide hydrochloride and 3.8 g. of o-toluic acid chloride is heated under stirring at about 120° C. After cooling and addition of diethyl ether, the hydrochloride of the triazole is collected on filter and then suspended in a sodium bicarbonate aqueous solution. The free base is extracted with diethyl ether and the organic phase, after drying over sodium sulfate, is evaporated. The crude compound is purified by distillation at 160° C./0.1 mm Hg. Yield 76%.

المصدر