تفاعل #5491

معادلة التفاعل

Trans 3-mercaptomethyl-2-oxo-1-azacyclodecane-10-carboxylic acid

Acetyl chloride

→

trans 3-(acetylthiomethyl)-2-oxo-1-azacyclodecane-10-carboxylic acid

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction is quenched
2. 2
   درجة الحرارةby cooling to 0° C.
3. 3
   workup.ADDITIONadding concentrated hydrochloric acid (20 mL)
4. 4
   workup.ADDITIONdiluting with water
5. 5
   استخلاصextracting several times with ethyl acetate
6. 6
   تجفيفThe combined organic layers are dried (MgSO4)
7. 7
   أخرىthe solvent is evaporated

الإجراء التجريبي

Trans 3-mercaptomethyl-2-oxo-1-azacyclodecane-10-carboxylic acid (0.75 g, 3.06 mmol) is dissolved in pyridine (20 mL). Acetyl chloride (0.26 g, 3.37 mmol) is added, and the reaction is stirred at room temperature overnight. The reaction is quenched by cooling to 0° C., adding concentrated hydrochloric acid (20 mL), diluting with water, and extracting several times with ethyl acetate. The combined organic layers are dried (MgSO4), and the solvent is evaporated to give trans 3-(acetylthiomethyl)-2-oxo-1-azacyclodecane-10-carboxylic acid, MS:M+1=288.

المصدر