تفاعل #54886

معادلة التفاعل

4-acetoxy-5-propoxy-1-pentanol tosylate

sodium iodide

→

crude title compound

4-Acetoxy-5-propoxy-1-iodopentane

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitated sodium tosylate is filtered off
2. 2
   أخرىMost of the acetone is evaporated from the filtrate
3. 3
   workup.ADDITIONthe residue is treated with 300 ml
4. 4
   غسيلwashed with dilute sodium thiosulfate solution, water, and brine
5. 5
   تجفيفdried over sodium sulfate
6. 6
   workup.DISTILLATIONThe solvent is distilled in vacuo

الإجراء التجريبي

A solution of 4-acetoxy-5-propoxy-1-pentanol tosylate (61.5 g., 0.179 mole) and sodium iodide (79.5 g., 0.53 mole) in acetone (500 ml.) is allowed to stand at 25°-27° C. for 18 hours. The precipitated sodium tosylate is filtered off. Most of the acetone is evaporated from the filtrate and the residue is treated with 300 ml. of water. The oily product is taken up in ether, washed with dilute sodium thiosulfate solution, water, and brine, and dried over sodium sulfate. The solvent is distilled in vacuo to give a quantitative yield of the crude title compound as a yellowish oil which is used without further purification.

المصدر