تفاعل #54874

معادلة التفاعل

5-chloro-2-pentanone

1-bromopentane

magnesium

Acetic anhydride

→

title compound

1-Chloro-4-acetoxy-4-methylnonane

المذيبات

Water

ether

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled to 15° C
2. 2
   workup.WAITto stand for 20 hours
3. 3
   أخرىthe ether layer is separated
4. 4
   غسيلwashed with brine
5. 5
   تجفيفdried over sodium sulfate
6. 6
   workup.DISTILLATIONDistillation

الإجراء التجريبي

To the Grignard reagent prepared from 1-bromopentane (4.8 g., 0.04 mole) and magnesium (0.96 g., 0.04 mole) in ether is added 5-chloro-2-pentanone (6.0 g., 0.04 mole). The reaction mixture is stirred at 25° C. for 1 hour and then cooled to 15° C. Acetic anhydride (6 ml., excess) is added carefully and the solution is allowed to stand for 20 hours. Water is added, and the ether layer is separated, washed with brine, and dried over sodium sulfate. Distillation affords the title compound in 4.3 g. (46%) yield, b.p. 88° C. (0.1 mm.).

المصدر