تفاعل #54830

معادلة التفاعل

dimethylformamide

sodium hydride

dimethylformamide

methyliodide

ethyl 3-hydroxy-4-cyclohexylphenylglyoxylate

→

ethyl 3-methoxy-4-cyclohexylphenylglyoxylate

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGto stir overnight at room temperature
2. 2
   استخلاصthe resulting mixture is extracted well with ether
3. 3
   استخلاصThe ether extract
4. 4
   غسيلis washed with water
5. 5
   تجفيفdried over sodium sulfate
6. 6
   أخرىevaporated to dryness
7. 7
   workup.DISTILLATIONdistilled

الإجراء التجريبي

To a stirred suspension of 0.01 moles of sodium hydride in 25 ml. of dry dimethylformamide which has been cooled to 0° C. is added dropwise a solution of 0.01 moles of ethyl 3-hydroxy-4-cyclohexylphenylglyoxylate in 10 ml. of dimethylformamide. The reaction mixture is stirred for 15 minutes and 0.015 moles of methyliodide is then added dropwise. The mixture is allowed to stir overnight at room temperature. 200 ml. of water is added and the resulting mixture is extracted well with ether. The ether extract is washed with water, dried over sodium sulfate, evaporated to dryness and distilled to obtain ethyl 3-methoxy-4-cyclohexylphenylglyoxylate.

المصدر