تفاعل #547778

معادلة التفاعل

potassium hydroxide

Salicylaldehyde

2-methylthiazole

hydrochloric acid

→

title compound

المردود 39.5%

2-(2′-hydroxystyryl)benzothiazole

المردود 39.5%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was cooled
2. 2
   غسيلThe aqueous layer was washed with ether
3. 3
   استخلاصextracted again with ethyl acetate
4. 4
   أخرىThe organic solvent was dried
5. 5
   تركيزconcentrated

الإجراء التجريبي

Salicylaldehyde (6.1 g) and 2-methylthiazole (7.5 g) were mixed and conc. hydrochloric acid (1.5 ml) was added thereto. The mixture was stirred with heating at 100° C. for 9 hr. The reaction mixture was cooled, and aqueous potassium hydroxide solution was added. The aqueous layer was washed with ether and made acidic with hydrochloric acid and extracted again with ethyl acetate. The organic solvent was dried and concentrated to give the title compound (2.5 g) as pale-yellow crystals, melting point 235–236° C.

المصدر