تفاعل #547527

معادلة التفاعل

5-Hydroxy-6-methoxy-indan-1-one

5-hydroxy-6-methoxy-indan-1-one

Intermediate H

5-hydroxy-6-methoxy-indan-1-one

2-(3-chloro-propoxy)-tetrahydro-pyran

Compound 18a

2-(3-chloro-propoxy)-tetrahydro-pyran

potassium carbonate

→

6-Methoxy-5-[3-(tetrahydro-pyran-2-yloxy)-propoxy]-indan-1-one

المذيبات

DMF

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed 3 times with water
2. 2
   تجفيفAfter drying over sodium sulfate
3. 3
   أخرىthe solvent was removed in vacuo

الإجراء التجريبي

A mixture of 5-Hydroxy-6-methoxy-indan-1-one (Intermediate H, 2.98 g, 0.017 mole), 2-(3-chloro-propoxy)-tetrahydro-pyran (Compound 18a) (6.0 g, 0.034 mole), and potassium carbonate (10.0 g, 0.0725 mole) were stirred in 50 mL of DMF at 80° C. overnight under Argon. The reaction mixture was then diluted with 200 mL of ethyl acetate and washed 3 times with water. After drying over sodium sulfate, the solvent was removed in vacuo. The crude material solidified on standing to yield the title compound, 6-Methoxy-5-[3-(tetrahydro-pyran-2-yloxy)-propoxy]-indan-1-one. MS m/z 309 (M+H)+.

المصدر