تفاعل #54736

معادلة التفاعل

2-(4-isobutylphenyl)propionic acid

sulfuric acid

n-propyl alcohol

→

2-(4-isobutylphenyl)propionic acid-n-propyl ester

المردود 89.7%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 6 hours
2. 2
   درجة الحرارةAfter cooling, to the mixture
3. 3
   استخلاصThe resulting mixture was extracted with ether
4. 4
   أخرىThe ether was removed by distillation from the
5. 5
   استخلاصextract
6. 6
   أخرىto leave an oily product
7. 7
   workup.DISTILLATIONThis product was distilled in vacuo

الإجراء التجريبي

A mixture of 5 g of 2-(4-isobutylphenyl)propionic acid, 7.3 g of n-propyl alcohol and 7.1 g of sulfuric acid was refluxed for 6 hours. After cooling, to the mixture was added ice-water. The resulting mixture was extracted with ether, and the extract was dehydrated. The ether was removed by distillation from the extract to leave an oily product. This product was distilled in vacuo to give 5.4 g of 2-(4-isobutylphenyl)propionic acid-n-propyl ester as a colorless oil, boiling at 100°-103° C./0.3 mmHg. Mass spectrum: parent ion 248 m/e.

المصدر