تفاعل #54730

معادلة التفاعل

sodium

cyclopropylmethyl alcohol

2-(p-isobutylphenyl)propionic acid methyl ester

water

→

2-(p-isobutylphenyl)propionic acid cyclopropylmethyl ester

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe whole was refluxed for 10 hours
2. 2
   أخرىthe solvent was removed by distillation under reduced pressure
3. 3
   أخرىto leave a residue
4. 4
   استخلاصThe resulting mixture was extracted with ether
5. 5
   غسيلthe extract was washed sufficiently with water
6. 6
   أخرىThe ether was removed by distillation
7. 7
   أخرىto leave a residual oily product
8. 8
   workup.DISTILLATIONThis product was then distilled under reduced pressure

الإجراء التجريبي

A mixture of 0.05 g of sodium in 20 ml of cyclopropylmethyl alcohol was heated at 50° C. for 5 hours. To the mixture was added 2.2 g of 2-(p-isobutylphenyl)propionic acid methyl ester and the whole was refluxed for 10 hours. After the reaction was completed, the solvent was removed by distillation under reduced pressure to leave a residue, to which was added water. The resulting mixture was extracted with ether, and the extract was washed sufficiently with water and then dehydrated. The ether was removed by distillation to leave a residual oily product. This product was then distilled under reduced pressure to yield 1.38 g of 2-(p-isobutylphenyl)propionic acid cyclopropylmethyl ester as a colorless oil, boiling at 109°-111° C./1 mmHg. Analysis-Calculated for C17H24O2 : C, 78.42; H, 9.29. Found: C, 78.19; H, 9.22.

المصدر