تفاعل #54725

معادلة التفاعل

2-(p-isobutylphenyl)propionic acid sodium salt

dimethylaminoethyl chloride

→

2-(p-isobutylphenyl)propionic acid dimethylaminoethyl ester

المردود 87.3%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 12 hours
2. 2
   أخرىA solid mass produced
3. 3
   ترشيحwas filtered off
4. 4
   workup.DISTILLATIONthe benzene was distilled away from the filtrate under reduced pressure
5. 5
   أخرىto leave an oily residue
6. 6
   workup.DISTILLATIONThis redidue was distilled under reduced pressure

الإجراء التجريبي

A mixture of 3.3 g of 2-(p-isobutylphenyl)propionic acid sodium salt, 2.3 g of dimethylaminoethyl chloride and 30 ml of benzene was refluxed for 12 hours. A solid mass produced was filtered off, and the benzene was distilled away from the filtrate under reduced pressure to leave an oily residue. This redidue was distilled under reduced pressure to give 3.5 g of 2-(p-isobutylphenyl)propionic acid dimethylaminoethyl ester as a colorless oil, boiling at 133°-136° C./1 mmHg. Analysis-Calculated for C17H27NO2 : C, 73.61; H, 9.81; N, 5.05. Found: C, 73.50; H, 9.72; N, 5.02. The infrared spectrum showed strong C=O absorption at 1730 cm-1 characteristic for ester. Mass spectrum: parent ion 277 m/e.

المصدر