تفاعل #54708

معادلة التفاعل

3-(2-isopropylaminopropyl)-4-(4-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone

methyl iodide

potassium carbonate

→

3-[2-(N-isopropyl-N-methylamino)-propyl]-4-(4-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for five hours
2. 2
   أخرىevaporated
3. 3
   استخلاصthe suspension extracted with diethyl ether
4. 4
   أخرىThe extract is dried
5. 5
   أخرىevaporated
6. 6
   أخرىthe residue crystallized from ethanol-water

الإجراء التجريبي

The mixture of 8.23 g of 3-(2-isopropylaminopropyl)-4-(4-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone, 2.25 ml of methyl iodide, 3.59 g of potassium carbonate and 100 ml of absolute ethanol is refluxed for five hours and evaporated. The residue is suspended in 100 ml of water and the suspension extracted with diethyl ether. The extract is dried, evaporated and the residue crystallized from ethanol-water to yield the 3-[2-(N-isopropyl-N-methylamino)-propyl]-4-(4-methoxyphenyl)-1,5,6,7-tetrahydro-2H-azepinone melting at 86°-88°.

المصدر