تفاعل #54691

معادلة التفاعل

dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide

3-pyrroline

→

dimethyl 6-(3-pyrrolin-1-yl)-2,4-pyrimidine-dicarbamate-3-oxide

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONA suspension of 12.5 g
2. 2
   أخرىThe white precipitate formed
3. 3
   ترشيحis filtered off
4. 4
   أخرىrecrystallized from a mixture of methylene chloride and methanol, there

الإجراء التجريبي

A suspension of 12.5 g. of dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide in 100 ml. of methylene chloride is treated with 15 g. of 3-pyrroline and the mixture is stirred at room temperature under an argon atmosphere for 26 hours. The white precipitate formed is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-(3-pyrrolin-1-yl)-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 206° C. (decomposition).

المصدر