تفاعل #54689

معادلة التفاعل

dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide

piperidine

→

dimethyl 6-piperidino-2,4-pyrimidine-dicarbamate-3-oxide

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONA suspension of 7.5 g
2. 2
   أخرىThe white precipitate formed
3. 3
   ترشيحis filtered off
4. 4
   أخرىrecrystallized from a mixture of methylene chloride and methanol, there

الإجراء التجريبي

A suspension of 7.5 g. of dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide in 35 ml. of methylene chloride is treated with 14.5 ml. of piperidine and the mixture is stirred at room temperature under an argon atmosphere for 18 hours. The white precipitate formed is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-piperidino-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 202° C. (decomposition).

المصدر