تفاعل #54591

معادلة التفاعل

water

Chloroform

potassium phthalimide

ethyl-2-bromopentanoate

→

ethyl α-phthalimidopentanoate

المذيبات

DMF

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe phases are separated
2. 2
   استخلاصthe aqueous phase is extracted with chloroform
3. 3
   استخلاصextracted with 0.1 N sodium hydroxide and with water
4. 4
   تجفيفAfter drying over sodium sulfate
5. 5
   أخرىthe chloroform is removed

الإجراء التجريبي

To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.

المصدر