تفاعل #54585

معادلة التفاعل

1-chloro-7-(bicyclo-[3.2.1]oct-2-yl)-1E-hepten-3-one

sodium iodide

→

1-iodo-7-(bicyclo[3.2.1]oct-2-yl)-1-E-hepten-3-one

المردود 88.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed in vacuo
2. 2
   استخلاصextracted three times with 30 ml portions of ether
3. 3
   غسيلThe combined ether extracts were washed with aqueous sodium thiosulfate
4. 4
   تجفيفdried (MgSO4)
5. 5
   أخرىevaporated in vacuo

الإجراء التجريبي

A solution of 3.2 g (13 mmol) of 1-chloro-7-(bicyclo-[3.2.1]oct-2-yl)-1E-hepten-3-one and 7.5 g (50 mmol) of sodium iodide in 25 ml of dry acetone (distilled from potassium carbonate) was refluxed for 18 hr under nitrogen. The solvent was removed in vacuo, and the residue was taken up in 50 ml of water and then extracted three times with 30 ml portions of ether. The combined ether extracts were washed with aqueous sodium thiosulfate, dried (MgSO4) and evaporated in vacuo to yield 3.8 g (88%) of 1-iodo-7-(bicyclo[3.2.1]oct-2-yl)-1-E-hepten-3-one.

المصدر