تفاعل #543539

معادلة التفاعل

[3-(2-carboxyethyl)]-3-nitropentane-1,5-dicarboxylic acid

cesium carbonate

benzylbromide

→

benzyl ester

المردود 82.2%

1,5-Bis(benzyloxycarbonyl)-3-[2-(benzyloxycarbony)ethyl]-3-nitro pentane

المردود 82.2%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   ترشيحInorganic salts were filtered
2. 2
   غسيلthe salts washed with acetonitrile
3. 3
   أخرىevaporated
4. 4
   أخرىto obtain an oil
5. 5
   أخرىPurification by chromatography over silica gel (hexane: ethyl acetate, 7:3)

الإجراء التجريبي

To a mixture of [3-(2-carboxyethyl)]-3-nitropentane-1,5-dicarboxylic acid (2.8 g, 0.01 mole) (prepared as described by James K. Young et al., Macromolecules, 1994, 27, 3464-34-71) and cesium carbonate (3.25 g, 0.025 mol) in acetonitrile (20.0 mL) was added benzylbromide (8.55 g, 6.0 mL, 0.05 mole) and the mixture stirred at RT for 24 h. Inorganic salts were filtered and the salts washed with acetonitrile. The filtrate and the washings were combined and evaporated to obtain an oil. Purification by chromatography over silica gel (hexane: ethyl acetate, 7:3) afforded the benzyl ester (40) as colorless viscous oil (4.5 g, yield: 82%). Mass Spectrum (M+H)hu +=548.

المصدر