تفاعل #543538

معادلة التفاعل

isoserine

methanol

HCl

HCl

→

product

المردود 92.0%

Methyl 3-amino-2-hydroxypropionate hydrochloride

المردود 92.0%

ظروف التفاعل

المعالجة

1. 1
   workup.DISSOLUTIONThe solid material slowly dissolved
2. 2
   أخرىto yield a pale yellow liquid after a few minutes
3. 3
   أخرىExcess HCl gas was removed
4. 4
   أخرىby bubbling nitrogen into the reaction mixture
5. 5
   أخرىthe solvent was removed under reduced pressure

الإجراء التجريبي

A suspension of isoserine (18) (20.0 g, 0.19 mol) in anhydrous methanol (100 mL) was saturated with HCl gas at 0° C. while being stirred with exclusion of moisture. The solid material slowly dissolved to yield a pale yellow liquid after a few minutes. The HCl saturated solution was stirred overnight (20 h) at room temperature. Excess HCl gas was removed by bubbling nitrogen into the reaction mixture and the solvent was removed under reduced pressure to yield the product as a syrup (27.1 g; yield 92%) Mass Spectrum M+H 120. The product was immediately taken to the next step without further purification.

المصدر