تفاعل #54314

معادلة التفاعل

Dimethyl 2-vinylglutamate hydrochloride

sodium carbonate

→

5-methoxycarbonyl-5-vinyl-2-pyrrolidone

المذيبات

2-methoxyethanol

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe resulting mixture extracted with dichloromethane
2. 2
   أخرىThe organic phase is dried
3. 3
   تركيزconcentrated
4. 4
   أخرىto afford the free base which
5. 5
   درجة الحرارةheated
6. 6
   درجة الحرارةunder reflux for 2 hours
7. 7
   أخرىThe solvent is then removed in vacuo

الإجراء التجريبي

Dimethyl 2-vinylglutamate hydrochloride (570 mg, 2 mM), is treated with saturated aqueous sodium carbonate (20 ml) and the resulting mixture extracted with dichloromethane. The organic phase is dried and concentrated to afford the free base which is dissolved in 2-methoxyethanol (20 ml) and heated under reflux for 2 hours. The solvent is then removed in vacuo to afford 5-methoxycarbonyl-5-vinyl-2-pyrrolidone.

المصدر