تفاعل #543097

ord-622e3e675a384c18b597715b8e805b30

معادلة التفاعل

CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12.O=C(O)CC(O)(CC(=O)O)C(=O)O
Sildenafil citrate
Cl
HCl
CO
methanol
→
CCCc1nn(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)[nH]c12.Cl
Sildenafil HCl

المتفاعلات

CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12.O=C(O)CC(O)(CC(=O)O)C(=O)O
Sildenafil citrate
Cl
HCl
CO
methanol

الكواشف

لا شيء

المذيبات

CCO
ethanol

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىreacted at 50° C. for 10 mins
  2. 2
    workup.WAITfor incubating over night
  3. 3
    أخرىcrystallization
  4. 4
    ترشيحThen, the crystal is filtrated

الإجراء التجريبي

Sildenafil citrate (9.5 g) is dissolved in a mixture of ethanol (10 mL) and HCl (1N, 60 mL), then reacted at 50° C. for 10 mins. Under room temperature, the methanol is added for incubating over night and crystallization. Then, the crystal is filtrated to obtain precipitate of Sildenafil HCl (6.4 g) for use.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08497370B2uspto-grants-2013_07