تفاعل #543096

معادلة التفاعل

Sildenafil citrate

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Sildenafil

المذيبات

ethanol

Ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىto obtain a white precipitate
2. 2
   workup.ADDITIONThe solution is poured out
3. 3
   غسيلto wash out the unreacted Sildenafil, over night
4. 4
   درجة الحرارةwarmed in water bath at 50° C.
5. 5
   درجة الحرارةcooled at room temperature over night

الإجراء التجريبي

20 g of sodium CMC is dissolved in water to form a 5% viscous aqueous solution (40 ml). Sildenafil citrate (13.3 g) is added to the solution and the mixture is stirred at 50° C. for 1 hr to obtain a white precipitate. The solution is poured out then the ethanol (100 ml) is added for dehydration. Ethanol (100 ml) is added additionally to wash out the unreacted Sildenafil, over night and warmed in water bath at 50° C. and cooled at room temperature over night to obtain the precipitate of Sildenafil-CMC complex (29.6 g).

المصدر