تفاعل #5430

معادلة التفاعل

potassium hydroxide

4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide

→

5-tert-Butylaminocarbonyl-2-methylthiothiazole-4-carboxylic acid

المذيبات

water

water ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was refluxed for 2 hours
2. 2
   أخرىThe solvent mixture was then removed under reduced pressure
3. 3
   ترشيحThe precipitated product was filtered off
4. 4
   أخرىdried

الإجراء التجريبي

0.82 g (14.6 mmol) of potassium hydroxide in 10 ml of water was added to a solution of 4.00 g (13.2 mmol) of 4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide in 50 ml of water/ethanol (2:1), and the mixture was refluxed for 2 hours. The solvent mixture was then removed under reduced pressure and the residue was taken up in 50 ml of water and acidified with concentrated hydrochloric acid. The precipitated product was filtered off and dried.

المصدر