تفاعل #5423

معادلة التفاعل

N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea

dibromoethane

potassium carbonate

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine

المردود 83.1%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed by distillation
2. 2
   استخلاصthe residue was extracted with diethyl ether
3. 3
   غسيلThe extract was washed with water
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   تركيزconcentrated under reduced pressure
6. 6
   أخرىThe residue was recrystallized from a mixture of hexane and ethanol

الإجراء التجريبي

A solution of N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea (1.8 g), dibromoethane (1.29 g) and anhydrous potassium carbonate (2.6 g) in acetone (20 ml) was refluxed for 5 hours. The solvent was removed by distillation, and the residue was extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from a mixture of hexane and ethanol to give 1.63 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine. m.p., 75.8° C.

المصدر