تفاعل #5419

معادلة التفاعل

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromothiazoline

tributyltin hydride

benzoyl peroxide

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazoline

المردود 75.8%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed by distillation
2. 2
   غسيلthe residue was washed with hexane
3. 3
   أخرىRecrystallization
4. 4
   workup.ADDITIONfrom a mixture of hexane and ethanol

الإجراء التجريبي

A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromothiazoline (4.7 g), tributyltin hydride (6.9 g) and a catalytic amount of benzoyl peroxide in tetrahydrofuran (100 ml) was refluxed for 10 hours. The solvent was removed by distillation, and the residue was washed with hexane. Recrystallization from a mixture of hexane and ethanol gave 2.85 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazoline (Compound (xii)).

المصدر