تفاعل #5418

معادلة التفاعل

2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline

hydrochloric acid

→

2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline

المردود 46.5%

المذيبات

ethanol water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 3 hours
2. 2
   أخرىEthanol was removed by distillation under reduced pressure
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   أخرىThe solvent was removed by distillation under reduced pressure

الإجراء التجريبي

A mixture of 2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline (1 g) and hydrochloric acid (38 %, 4 ml) in ethanol-water (1:2, 15 ml) was refluxed for 3 hours. Ethanol was removed by distillation under reduced pressure, and the residue was neutralized with potassium carbonate, extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 0.4 g of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound (xi)).

المصدر