تفاعل #5411

معادلة التفاعل

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine

N-bromosuccinimide

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromothiazoline

المردود 45.3%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   غسيلthe reaction mixture was washed with an aqueous sodium sulfite solution
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   أخرىThe solvent was removed under reduced pressure

الإجراء التجريبي

A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine (1.6 g) and N-bromosuccinimide (2 g) in chloroform (50 ml) was refluxed for 10 hours. After cooling, the reaction mixture was washed with an aqueous sodium sulfite solution and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was subjected to column chromatography to give 0.9 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromothiazoline (Compound No. 30).

المصدر