تفاعل #540929

ord-d2d856c33fcb47a1a1d57b441fa41028

معادلة التفاعل

O=C([C@H]1COc2ccccc2O1)N1CCC[C@@H](c2ccc(F)cc2)C1
(R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(S*)-3-(4-fluorophenyl)piperidin-1-yl]methanone
→
Fc1ccc([C@@H]2CCCN(C[C@H]3COc4ccccc4O3)C2)cc1
title compound
Fc1ccc([C@@H]2CCCN(C[C@H]3COc4ccccc4O3)C2)cc1
(S*)-1-[(S)-1-(2,3-Dihydrobenzo[1,4]dioxin-2-yl)methyl]-3-(4-fluorophenyl)piperidine

المتفاعلات

O=C([C@H]1COc2ccccc2O1)N1CCC[C@@H](c2ccc(F)cc2)C1
(R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(S*)-3-(4-fluorophenyl)piperidin-1-yl]methanone

الكواشف

لا شيء

المذيبات

C1CCOC1
THF

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

(R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(S*)-3-(4-fluorophenyl)piperidin-1-yl]methanone (20 mg, 0.058 mmol) was treated with BH3 THF according to the above general procedure. Flash chromatography gave the title compound.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08492549B2uspto-grants-2013_07