تفاعل #54052

ord-9ed43edf77e04ccc9d4905866af16f7a

معادلة التفاعل

COc1ccccc1-c1ccc2c(c1)C(CSC(C)=O)=CC(C)(C)N2
Thioacetic acid S-[6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinolin-4-ylmethyl] ester
COc1ccccc1-c1ccc2c(c1)C(CBr)=CC(C)(C)N2
4-bromomethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline
CC(O)=S
thioacetic acid
CCN(CC)CC
triethylamine
COc1ccccc1-c1ccc2c(c1)C(CNc1ccccc1)=CC(C)(C)N2
title compound
COc1ccccc1-c1ccc2c(c1)C(CNc1ccccc1)=CC(C)(C)N2
[6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinolin-4-ylmethyl]phenylamine

المذيبات

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Thioacetic acid S-[6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinolin-4-ylmethyl] ester 776 mg of 4-bromomethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline in 16 mL of methylene chloride was treated with 155 μL of thioacetic acid and 303 μL of triethylamine to give 100 mg of the title compound as a foam.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06858627B2uspto-grants-2005_02